Important Publications by FOR5815 Researchers

2025

Dengue virus is particularly sensitive to interference with long-chain fatty acid elongation and desaturation
Hehner J, Ludenia L, Bierau L, Schöbel A, Schauflinger M, Grande YF, Schwudke D, Herker E
J Biol Chem 301(3):108222 2025
doi: 10.1016/j.jbc.2025.108222 PMID: 39863099 PMCID: PMC11908578

Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation
Snaebjornsson MT, Poeller P, Komkova D, Röhrig F, Schlicker L, Winkelkotte AM, Chaves-Filho AB, Al-Shami KM, Caballero CD, Koltsaki I, Vogel FCE, Frias-Soler RC, Rudalska R, Schwarz JD, Wolf E, Dauch D, Steuer R, Schulze A
Nat Metab Feb;7(2):348-366 2025
doi: 10.1038/s42255-024-01201-w PMID: 39833612 PMCID: PMC11860237

2024

Proximity labeling of host factor ANXA3 in HCV infection reveals a novel LARP1 function in viral entry
Bley H, Krisp C, Schöbel A, Hehner J, Schneider L, Becker M, Stegmann C, Heidenfels E, Nguyen-Dinh V, Schlüter H, Gerold G, Herker E
J Biol Chem 300(5):107286 2024
doi: 10.1016/j.jbc.2024.107286 PMID: 38636657 PMCID: PMC11101947

Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer
Buglakova E, Ekelöf M, Schwaiger-Haber M, Schlicker L, Molenaar MR, Shahraz M, Stuart L, Eisenbarth A, Hilsenstein V, Patti GJ, Schulze A^#, Snaebjornsson MT^#, Alexandrov T^# - ^#shared corresponding authorship
Nat Metab Sep;6(9):1695-1711 2024
doi: 10.1038/s42255-024-01118-4 PMID: 39251875 PMCID: PMC11422168

A metabolically controlled contact site between vacuoles and lipid droplets in yeast
Diep DTV, Collado J, Hugenroth M, Fausten RM, Percifull L, Wälte M, Schuberth C, Schmidt O, Fernández-Busnadiego R, Bohnert M
Dev Cell 59, 740 2024
doi: 10.1016/j.devcel.2024.01.016 PMID: 38367622

Zooming into lipid droplet biology through the lens of electron microscopy
Dudka W, Salo VT, Mahamid J
FEBS Letters 598(10):1127-1142 2024
doi: 10.1002/1873-3468.14899 PMID: 38726814

Glycerophospholipid remodeling is critical for orthoflavivirus infection
Hehner J, Schneider L, Woitalla A, Ott B, Vu KCT, Schöbel A, Hain T, Schwudke D, Herker E
Nat Commun 15(1):8683 2024
doi: 10.1038/s41467-024-52979-y PMID: 39375358 PMCID: PMC11458896

Lipid Droplets in Virus Replication
Herker E
FEBS Lett 598(10):1299-1300 2024
doi: 10.1002/1873-3468.14819 PMID: 38348563

A spatiotemporal proteomic map of human adipogenesis
Klingelhuber F, Frendo-Cumbo S, Omar-Hmeadi M, Massier L, Kakimoto P, Taylor AJ, Couchet M, Ribicic S, Wabitsch M, Messias AC, Iuso A, Muller TD, Ryden M, Mejhert N and Krahmer N
Nat Metab 6:861-879 2024
doi: 10.1038/s42255-024-01025-8 PMID: 38565923 PMCID: PMC11132986

mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism
Levy T, Voeltzke K, Hruby L, Alasad K, Bas Z, Snaebjörnsson M, Marciano R, Scharov K, Planque M, Vriens K, Christen S, Funk CM, Hassiepen C, Kahler A, Heider B, Picard D, Lim JKM, Stefanski A, Bendrin K, Vargas-Toscano A, Kahlert UD, Stühler K, Remke M, Elkabets M, Grünewald TGP, Reichert AS, Fendt SM, Schulze A, Reifenberger G, Rotblat B, Leprivier G
Nat Commun 15(1):4083 2024
doi: 10.1038/s41467-024-48386-y PMID: 38744825 PMCID: PMC11094136

EPAC1 enhances brown fat growth and beige adipogenesis
Reverte-Salisa L, Siddig S, Hildebrand S, Yao X, Zurkovic J, Jaeckstein MY, Heeren J, Lezoualc’h F, Krahmer N and Pfeifer A
Nat Cell Biol 26:113-123 2024
doi: 10.1038/s41556-023-01311-9 PMID: 38195707 PMCID: PMC10791580

Targeting MYC induces lipid droplet accumulation by upregulation of HILPDA in clear cell renal cell carcinoma
Sainero-Alcolado L, Garde-Lapido E, Snaebjörnsson MT, Schoch S, Stevens I, Ruiz-Pérez MV, Dyrager C, Pelechano V, Axelson H, Schulze A, Arsenian-Henriksson M.
Proc Natl Acad Sci U S A 121(7):e2310479121 2024
doi: 10.1073/pnas.2310479121 PMID: 38335255 PMCID: PMC10873620

Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lines and cerebral organoids
Schöbel A, Pinho Dos Reis V, Burkhard R, Hehner J, Schneider L, Schauflinger M, Vieyres G, Herker E
Commun Biol 7(1):1089 2024
doi: 10.1038/s42003-024-06776-4 PMID: 39237833 PMCID: PMC11377701

Lipids as mediators of cancer progression and metastasis
Vogel FCE, Chaves-Filho AB, Schulze A
Nat Cancer 5. 16 2024
doi: 10.1038/s43018-023-00702-z PMID: 38273023

2023

Convolutional networks for supervised mining of molecular patterns within cellular context
de Teresa-Trueba I, Goetz SK, Mattausch A, Stojanovska F, Zimmerli C, Toro-Nahuelpan M, Cheng DWC, Tollervey F, Pape C, Beck B, Kreshuk A, Mahamid J, Zaugg J
Nature Methods 20, 284–294 2023
doi: 10.1038/s41592-022-01746-2 PMID: 36690741 PMCID: PMC9911354

Light and electron microscopy continuum resolution imaging of 3D cell cultures
D’Imprima E, Garcia Montero M, Gawrzak S, Ronchi P, Zagoriy I, Schwab Y, Jechlinger M, Mahamid J
Cell 58 616-632 2023
doi: 10.1016/j.devcel.2023.03.001 PMID: 36990090 PMCID: PMC10114294

Genetically encoded multimeric tags for subcellular protein localization in cryo-EM
Fung HKH, Hayashi Y, Salo VT, Babenko A, Zagoriy I, Brunner A, Ellenberg J, Muller CW, Cuylen-Haering S, Mahamid J
Nat Methods 20, 1900 2023
doi: 10.1038/s41592-023-02053-0 PMID: 37932397 PMCID: PMC10703698

Quantification of Dolichyl Phosphates Using Phosphate Methylation and Reverse-Phase Liquid Chromatography-High Resolution Mass Spectrometry
Kale D^#, Kikul F, Phapale P, Beedgen L, Thiel C, Brügger B^# - ^#shared corresponding authorship
Anal Chem 95(6):3210-3217 2023
doi: 10.1021/acs. analchem.2c03623 PMID: 36716239 PMCID: PMC9933046

Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo
Kulaj K, Harger A, Bauer M, Caliskan OS, Gupta TK, Chiang DM, Milbank E, Reber J, Karlas A, Kotzbeck P, Sailer DN, Volta F, Lutter D, Prakash S, Merl-Pham J, Ntziachristos V, Hauner H, Pfaffl MW, Tschop MH, Muller TD, Hauck SM, Engel BD, Gerdes JM, Pfluger PT, Krahmer N and Stemmer K
Nat Commun 14:709 2023
doi: 10.1038/s41467-023-36148-1 PMID: 36759608 PMCID: PMC9911726

The role of human lipoproteins for hepatitis C virus persistence
Vieyres G, Pietschmann T
Curr Opin Virol 60, 101327 2023
doi: 10.1016/j.coviro.2023.101327 PMID: 37031484

2022

Spatial proteomics in three-dimensional intact specimens
Bhatia HS, Brunner AD, Ozturk F, Kapoor S, Rong Z, Mai H, Thielert M, Ali M, Al-Maskari R, Paetzold JC, Kofler F, Todorov MI, Molbay M, Kolabas ZI, Negwer M, Hoeher L, Steinke H, Dima A, Gupta B, Kaltenecker D, Caliskan OS, Brandt D, Krahmer N, Muller S, Lichtenthaler SF, Hellal F, Bechmann I, Menze B, Theis F, Mann M and Erturk A
Cell 185:5040-5058 e5019 2022
doi: 10.1016/j.cell.2022.11.021 PMID: 36563667

Phosphoproteomics and Organelle Proteomics in Pancreatic Islets
Caliskan OS, Massacci G, Krahmer N, Sacco F
Methods Mol Biol 2456, 123 2022
doi: 10.1007/978-1-0716-2124-0_9 PMID: 35612739

Introducing the Lipidomics Minimal Reporting Checklist
McDonald JG, Ejsing CS, Kopczynski D, Holcapek M, Aoki J, Arita M, Arita M, Baker ES, Bertrand-Michel J, Bowden JA, Brugger B, Ellis SR, Fedorova M, Griffiths WJ, Han X, Hartler J, Hoffmann N, Koelmel JP, Kofeler HC, Mitchell TW, O’Donnell VB, Saigusa D, Schwudke D, Shevchenko A, Ulmer CZ, Wenk MR, Witting M, Wolrab D, Xia Y, Ahrends R, Liebisch G, Ekroos K
Nat Metab 4, 1086 2022
doi: 10.1038/s42255-022-00628-3 PMID: 35934691

The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology
Mejhert N, Gabriel KR, Frendo-Cumbo S, Krahmer N, Song J, Kuruvilla L, Chitraju C, Boland S, Jang DK, von Grotthuss M, Costanzo MC, Ryden M, Olzmann JA, Flannick J, Burtt NP, Farese RV, Jr. and Walther TC
Dev Cell 57:387-397 e384 2022
doi: 10.1016/j.devcel.2022.01.003 PMID: 35134345 PMCID: PMC9129885

Glycolytic flux-signaling controls mouse embryo mesoderm development
Miyazawa H^#, Snaebjornsson MT^#, Prior N, Kafkia E, Hammarén HM, Tsuchida-Straeten N, Patil KR, Beck M, Aulehla A - ^#contributed equally
Elife 11:e83299 2022
doi: 10.7554/eLife.83299 PMID: 36469462 PMCID: PMC9771359

Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine
Niemann B, Haufs-Brusberg S, Puetz L, Feickert M, Jaeckstein MY, Hoffmann A, Zurkovic J, Heine M, Trautmann EM, Muller CE, Tonjes A, Schlein C, Jafari A, Eltzschig HK, Gnad T, Bluher M, Krahmer N, Kovacs P, Heeren J and Pfeifer A
Nature 609:361-368 2022
doi: 10.1038/s41586-022-05041-0 PMID: 35790189 PMCID: PMC9452294

The glycolytic enzyme ALDOA and the exon junction complex protein RBM8A are regulators of ribosomal biogenesis
Schwarz JD, Lukassen S, Bhandare P, Eing L, Snaebjörnsson MT, García YC, Kisker JP, Schulze A, Wolf E
Front Cell Dev Biol 10:954358 2022
doi: 10.3389/fcell.2022.954358 PMID: 36187487 PMCID: PMC9515781

2021

Lipid Droplet Contact Sites in Health and Disease
Herker E, Vieyres G, Beller M, Krahmer N, Bohnert M
Trends Cell Biol 31(5):345-358 2021
doi: 10.1016/j.tcb.2021.01.004 PMID: 33546922

MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer
Kalogirou C, Linxweiler J, Schmucker P, Snaebjornsson MT, Schmitz W, Wach S, Krebs M, Hartmann E, Puhr M, Muller A, Spahn M, Seitz AK, Frank T, Marouf H, Buchel G, Eckstein M, Kubler H, Eilers M, Saar M, Junker K, Rohrig F, Kneitz B, Rosenfeldt MT, Schulze A
Nat Commun 12:5066 2021
doi: 10.1038/s41467-021-25325-9 PMID: 34417456 PMCID: PMC8379214

A Modular Platform for Automated Cryo-FIB Workflows
Klumpe S*, Fung HKH, Goetz SK, Zagoriy I, Hampoelz B, Zhang X, Erdmann PS, Baumbach J, Müller CW, Beck M, Plitzko JM, Mahamid J
eLife 10:e70506 2021
doi: 10.7554/eLife.70506 PMID: 34951584 PMCID: PMC8769651

Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
Malek M, Wawrzyniak AM, Koch P, Lüchtenborg C, Hessenberger M, Sachsenheimer T, Jang W, Brügger B, Haucke V
Nat Commun 12(1):2673 2021
doi: 10.1038/s41467-021-22882-x PMID: 33976123 PMCID: PMC8113574

Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins
Nůsková H, Serebryakova MV, Ferrer-Caelles A, Sachsenheimer T, Lüchtenborg C, Miller AK, Brügger B, Kordyukova LV, Teleman AA
Nat Commun 12:4590 2021
doi: 10.1038/s41467-021-24844-9 PMID: 34321466 PMCID: PMC8319428

Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex
Papagiannidis D, Bircham PW, Luchtenborg C, Pajonk O, Ruffini G, Brugger B, Schuck S
EMBO J 40, e107958 2021
doi: 10.1007/s00216-018-1517-5 PMID: 34617598 PMCID: PMC8591542

LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer
Rudalska R, Harbig J, Snaebjornsson MT, Klotz S, Zwirner S, Taranets L, Heinzmann F, Kronenberger T, Forster M, Cui W, D’Artista L, Einig E, Hinterleitner M, Schmitz W, Dylawerska A, Kang TW, Poso A, Rosenfeldt MT, Malek NP, Bitzer M, Laufer S, Pichler BJ, Popov N, Schulze A, Zender L, Dauch D
Nat Cancer 2(2):201-217 2021
doi: 10.1038/s43018-020-00168-3 PMID: 35122079

Inhibition of fatty acid synthesis induces differentiation and reduces tumor burden in childhood neuroblastoma
Ruiz-Pérez MV, Sainero-Alcolado L, Oliynyk G, Matuschek I, Balboni N, Ubhayasekera SJKA, Snaebjornsson MT, Makowski K, Aaltonen K, Bexell D, Serra D, Nilsson R, Bergquist J, Schulze A, Arsenian-Henriksson M
iScience 24(2):102128 2021
doi: 10.1016/j.isci.2021.102128 PMID: 33659885 PMCID: PMC7895756

Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation
Tabata K, Prasad V, Paul D, Lee JY, Pham MT, Twu WI, Neufeldt CJ, Cortese M, Cerikan B, Stahl Y, Joecks S, Tran CS, Luchtenborg C, V’Kovski P, Hormann K, Muller AC, Zitzmann C, Haselmann U, Beneke J, Kaderali L, Erfle H, Thiel V, Lohmann V, Superti-Furga G, Brugger B, Bartenschlager R
Nat Commun 12, 7276 2021
doi: 10.1038/s41467-021-27511-1 PMID: 34907161 PMCID: PMC8671429

PicPreview and PicSummary: Two Timesaving Plugins for the Fluorescence Microscopist
Vieyres G
Cells 10(4) :846 2021
doi: 10.3390/cells10040846 PMID: 33917996 PMCID: PMC8068365

2020

Grease on—Perspectives in lipid droplet biology
Beller M, Herker E, Füllekrug J
Semin Cell Dev Biol 108, 94 2020
doi: 10.1016/j.semcdb.2020.06.017 PMID: 32636101

Tether Me, Tether Me Not-Dynamic Organelle Contact Sites in Metabolic Rewiring
Bohnert M
Dev Cell 54, 212 2020
doi: 10.1016/j.devcel.2020.06.026 PMID: 32693056

CG32803 is the fly homolog of LDAF1 and influences lipid storage in vivo
Chartschenko E, Hugenroth M, Akhtar I, Droste A, Kolkhof P, Bohnert M, Beller M
Insect Biochem Mol Biol 133 103512 2020
doi: 10.1016/j.ibmb.2020.103512 PMID: 33307187

Hepatic lipid droplet homeostasis and fatty liver disease
Seebacher F, Zeigerer A, Kory N, Krahmer N
Semin Cell Dev Biol 108, 72 2020
doi: 10.1016/j.semcdb.2020.04.011 PMID: 32444289

Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer
Snaebjornsson MT, Janaki-Raman S, Schulze A
Cell metabolism 31, 62 2020
doi: 10.1016/j.cmet.2019.11.010 PMID: 31813823

Tailoring cryo-electron microscopy grids by photo-micropatterning for in-cell structural studies
Toro-Nahuelpan M, Zagoriy I, Senger F, Blanchoin L, Théry M, Mahamid J
Nature Methods 17, 50-54 2020
doi: 10.1038/s41592-019-0630-5 PMID: 31740821 PMCID: PMC6949126

Tracking hepatitis C virus interactions with the hepatic lipid metabolism – A hitchhiker´s guide to solve remaining translational research challenges in hepatitis C
Vieyres G, Pietschmann T
Chapter 66 of The Liver – Biology and Pathobiology, 6th edition. Edited by Irwin Arias, Harvey Alter, James Boyer, David Cohen, Snorri Torgeirsson, David Shafritz, and Allan Wolkoff ISBN: 978-1-119-43682-9 2020

The ATGL lipase cooperates with ABHD5 to mobilize lipids for HCV assembly and lipoprotein production
Vieyres G, Reichert I, Carpentier C, Vondran FW, Pietschmann T
PLoS Pathogens 16(6):e1008554 2020
doi: 10.1371/journal.ppat.1008554 PMID: 32542055 PMCID: PMC7316345

2019

Promethin is a conserved seipin partner protein
Castro IG, Eisenberg-Bord M, Persiani E, Rochford JJ, Schuldiner M, Bohnert M
Cells 8 2019
doi: 10.3390/cells8030268 PMID: 30901948 PMCID: PMC6468817

FSP1 is a glutathione-independent ferroptosis suppressor
Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Goya Grocin A, Xavier da Silva TN, Panzilius E, Scheel CH, Mourao A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, O’Donnell V, Proneth B, Popowicz GM, Pratt DA, Angeli JPF, Conrad M
Nature 575, 693 2019
doi: 10.1038/s41586-019-1707-0 PMID: 31634899

Identification of seipin-linked factors that act as determinants of a lipid droplet subpopulation
Eisenberg-Bord M, Mari M, Weill U, Rosenfeld-Gur E, Moldavski O, Castro IG, Soni KG, Harpaz N, Levine TP, Futerman AH, Reggiori F, Bankaitis VA, Schuldiner M, Bohnert M
J Cell Biol 217, 269 2019
doi: 10.1083/jcb.201704122 PMID: 29187527 PMCID: PMC5748981

Lipid droplet quantification based on iterative image processing
Exner T, Beretta CA, Gao Q, Afting C, Romero-Brey I, Bartenschlager R, Fehring L, Poppelreuther M, Füllekrug J
J Lipid Res 60, 1333 2019
doi: 10.1194/jlr.D092841 PMID: 30926625 PMCID: PMC6602134

An alternative membrane topology permits lipid droplet localization of peroxisomal fatty acyl-CoA reductase 1
Exner T, Romero-Brey I, Yifrach E, Rivera-Monroy J, Schrul B, Zouboulis CC, Stremmel W, Honsho M, Bartenschlager R, Zalckvar E, Poppelreuther M, Fullekrug J
J Cell Sci 132 2019
doi: 10.1242/jcs.223016 PMID:30745342

The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth
Gouw AM, Margulis K, Liu NS, Raman SJ, Mancuso A, Toal GG, Tong L, Mosley A, Hsieh AL, Sullivan DK, Stine ZE, Altman BJ, Schulze A, Dang CV, Zare RN, Felsher DW
Cell metabolism 30 2019
doi: 10.1016/j.cmet.2019.07.012 PMID: 31447321 PMCID: PMC6911354

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity
Hammerschmidt P, Ostkotte D, Nolte H, Gerl MJ, Jais A, Brunner HL, Sprenger HG, Awazawa M, Nicholls HT, Turpin-Nolan SM, Langer T, Krüger M, Brügger B, and Brüning JC
Cell 177:1536-1552 e1523 2019
doi: 10.1016/j.cell.2019.05.008 PMID: 31150623

Perilipin-2 is critical for efficient lipoprotein and hepatitis C virus particle production
Lassen S, Gruttner C, Nguyen-Dinh V, Herker E
J Cell Sci 132, jcs.217042 2019
doi: 10.1242/jcs.217042 PMID: 30559250

Liquid-crystalline phase transitions in lipid droplets are related to cellular states and specific organelle association
Mahamid J, Tegunov D, Maiser A, Arnold J, Leonhardt H, Plitzko, JM, Baumeister W
Proceedings of the National Academy of Sciences USA 116, 16866-16871 2019
doi: 10.1073/pnas.1903642116 PMID: 31375636 PMCID: PMC6708344

HCV Pit Stop at the Lipid Droplet: Refuel Lipids and Put on a Lipoprotein Coat before Exit
Vieyres G, Pietschmann T
Cells 8 2019
doi: 10.3390/cells8030233 PMID: 30871009 PMCID: PMC6468556

2018

Complex lipid metabolic remodeling is required for efficient hepatitis C virus replication
Hofmann S, Krajewski M, Scherer C, Scholz V, Mordhorst V, Truschow P, Schobel A, Reimer R, Schwudke D, Herker E
Biochim Biophys Acta Mol Cell Biol Lipids 1863, 1041 2018
doi: 10.1016/j.bbalip.2018.06.002 PMID: 29885363

Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis
Krahmer N, Najafi B, Schueder F, Quagliarini F, Steger M, Seitz S, Kasper R, Salinas F, Cox J, Uhlenhaut NH, Walther TC, Jungmann R, Zeigerer A, Borner GHH and Mann M
Dev Cell 47:205-221 e207 2018
doi: 10.1016/j.devcel.2018.09.017 PMID: 30352176

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma
Miess H, Dankworth B, Gouw AM, Rosenfeldt M, Schmitz W, Jiang M, Saunders B, Howell M, Downward J, Felsher DW, Peck B, Schulze A
Oncogene 37, 5434 2018
doi: 10.1038/s41388-018-0315-z PMID: 29872221 PMCID: PMC6173300

The metabolic capacity of lipid droplet localized acyl-CoA synthetase 3 is not sufficient to support local triglyceride synthesis independent of the endoplasmic reticulum in A431 cells
Poppelreuther M, Sander S, Minden F, Dietz MS, Exner T, Du C, Zhang I, Ehehalt F, Knuppel L, Domschke S, Badenhop A, Staudacher S, Ehehalt R, Stremmel W, Thiele C, Heilemann M, Fullekrug J
Biochim Biophys Acta Mol Cell Biol Lipids 1863, 614 2018
doi: 10.1016/j.bbalip.2018.03.003 PMID: 29526665

2017

Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development
Bulusu V^#, Prior N^#, Snaebjornsson MT^#, Kuehne A, Sonnen KF, Kress J, Stein F, Schultz C, Sauer U, Aulehla A - ^# contributed equally
Dev Cell 40(4):331-341.e4 2017
doi: 10.1016/j.devcel.2017.01.015 PMID: 28245920 PMCID: PMC5337618

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, Prokisch H, Trumbach D, Mao G, Qu F, Bayir H, Fullekrug J, Scheel CH, Wurst W, Schick JA, Kagan VE, Angeli JP, Conrad M
Nat Chem Biol 13, 91 2017
doi: 10.1038/nchembio.2239 PMID: 2784207 PMCID: PMC5610546

2016

Quantitative Lipid Droplet Proteome Analysis Identifies Annexin A3 as a Cofactor for HCV Particle Production
Rosch K, Kwiatkowski M, Hofmann S, Schobel A, Gruttner C, Wurlitzer M, Schluter H, Herker E
Cell Rep 16, 3219 2016
doi: 10.1016/j.celrep.2016.08.052 PMID: 27653686

ABHD5/CGI-58, the Chanarin-Dorfman syndrome protein, mobilises lipid stores for hepatitis C virus production
Vieyres G, Welsch K, Gerold G, Gentzsch J, Kahl S, Vondran FW, Kaderali L, Pietschmann T
PLoS Pathogens 12(4):e1005568 2016
doi: 10.1371/journal.ppat.1005568 PMID: 27124600 PMCID: PMC4849665

2015

Cryo-focused Ion Beam Sample Preparation for Imaging Vitreous Cells by Cryo-electron Tomography
Schaffer M, Engel BD, Laugks T, Mahamid J, Plitzko JM, Baumeister W
Bio Protoc 5 2015
doi: 10.21769/bioprotoc.1575 PMID: 27294174 PMCID: PMC4900445

2014

Role of the hypervariable region 1 (HVR1) for the interplay of hepatitis C virus with entry factors and lipoproteins
Bankwitz D, Vieyres G, Hueging K, Bitzegeio J, Doepke M, Chhatwal P, Haid S, Catanese MT, Zeisel MB, Nicosia A, Baumert TF, Kaderali L, Pietschmann T
Journal of Virology 88(21):12644-55 2014
doi: 10.1128/JVI.01145-14 PMID: 25142595 PMCID: PMC4248924

Fatty acid uptake and lipid storage induced by HIF-1alpha contribute to cell growth and survival after hypoxia-reoxygenation
Bensaad K, Favaro E, Lewis CA, Peck B, Lord S, Collins JM, Pinnick KE, Wigfield S, Buffa FM, Li JL, Zhang Q, Wakelam MJ, Karpe F, Schulze A, Harris AL
Cell reports 9, 349 2014
doi: 10.1016/j.celrep.2014.08.056 PMID: 25263561

Analysis of transmembrane domains and lipid modified peptides with matrix-assisted laser desorption ionization-time-of-flight mass spectrometry
Gerl MJ^#, Sachsenheimer T, Grzybek M, Coskun U, Wieland FT, Brügger B^# - ^#shared corresponding authorship
Anal Chem 86(8):3722-6 2014
doi: 10.1021/ac500446z PMID: 24628620

Apolipoprotein E codetermines tissue tropism of hepatitis C virus and is crucial for viral cell-to-cell transmission by contributing to a postenvelopment step of assembly
Hueging K, Doepke M, Vieyres G, Bankwitz D, Frentzen A, Doerrbecker J, Gumz F, Haid S, Wolk B, Kaderali L, Pietschmann T
J Virol 88, 1433 2014
doi: 10.1128/JVI.01815-13 PMID: 24173232 PMCID: PMC3911621

Differentially localized acyl-CoA synthetase 4 isoenzymes mediate the metabolic channeling of fatty acids towards phosphatidylinositol
Küch E-M, Vellaramkalayil R, Zhang I, Lehnen D, Brügger B, Stremmel W, Ehehalt R, Poppelreuther M, Füllekrug J
Biochim Biophys Acta 1841, 227 2014
doi: 10.1016/j.bbalip.2013.10.018 PMID: 24201376

2013

Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core
Camus G, Herker E, Modi AA, Haas JT, Ramage HR, Farese RV, Jr., Ott M
J Biol Chem 288, 9915 2013
doi: 10.1074/jbc.M112.434910 PMID: 39616949 PMCID: PMC11648214

Balancing the fat: lipid droplets and human disease
Krahmer N, Farese RV, Jr., Walther TC
EMBO Mol Med 5, 973 2013
doi: 10.1002/emmm.201100671 PMID: 23740690 PMCID: PMC3721468

Protein correlation profiles identify lipid droplet proteins with high confidence
Krahmer N, Hilger M, Kory N, Wilfling F, Stoehr G, Mann M, Farese RV, Jr. and Walther TC
Mol Cell Proteomics 12:1115-1126 2013
doi: 10.1074/mcp.M112.020230 PMID: 23319140 PMCID: PMC3650325

Subcellular localization and function of an epitope-tagged p7 viroporin in hepatitis C virus-producing cells
Vieyres G^#, Brohm C^#, Friesland M, Gentzsch J, Wölk B, Roingeard P, Steinmann E, Pietschmann T - ^# contributed equally
Journal of Virology 87(3):1664-78 2013
doi: 10.1128/JVI.02782-12 PMID: 23175364 PMCID: PMC3554161

Entry and replication of recombinant hepatitis C viruses in cell culture
Vieyres G, Pietschmann T
Methods 59, 233 2013
doi: 10.1016/j.ymeth.2012.09.005 PMID: 23009812

Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein
Vogt DA, Camus G, Herker E, Webster BR, Tsou CL, Greene WC, Yen TS, Ott M
PLoS Pathog 9, e1003302 2013
doi: 10.1371/journal.ppat.1003302 PMID: 23593007 PMCID: PMC3623766

2012

Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane
Bohnert M^#, Wenz LS^#, Zerbes RM^#, Horvath SE, Stroud DA, von der Malsburg K, Muller JM, Oeljeklaus S, Perschil I, Warscheid B, Chacinska A, Veenhuis M, van der Klei IJ, Daum G, Wiedemann N, Becker T, Pfanner N, van der Laan M - ^# contributed equally
Mol Biol Cell 23, 3948 2012
doi: 10.1091/mbc.E12-04-0295 PMID: 22918945 PMCID: PMC3469511

Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain
Contreras FX, Ernst AM, Haberkant P, Björkholm P, Lindahl E, Gonen B, Tischer C, Elofsson A, von Heijne G, Thiele C, Pepperkok R, Wieland F^#, Brügger B^# - ^#shared corresponding authorship
Nature 481:525-529 2012
doi: 10.1038/nature10742 PMID: 22230960

Outlook: Membrane junctions enable the metabolic trapping of fatty acids by intracellular acyl-CoA synthetases Füllekrug J, Ehehalt R, Poppelreuther M
Front Physiol 3 2012
doi: 10.3389/fphys.2012.00401 PMID: 23087649 PMCID: PMC3467455

The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake
Poppelreuther M, Rudolph B, Du C, Grossmann R, Becker M, Thiele C, Ehehalt R, Fullekrug J
J Lipid Res 53, 888 2012
doi: 10.1194/jlr.M024562 PMID: 22357706 PMCID: PMC3329388

2011

FATP4 contributes as an enzyme to the basal and insulin-mediated fatty acid uptake of C(2)C(1)(2) muscle cells
Digel M, Staffer S, Ehehalt F, Stremmel W, Ehehalt R, Fullekrug J
Am J Physiol Endocrinol Metab 301, E785 2011
doi: 10.1152/ajpendo.00079.2011 PMID: 21750264

A role for phosphatidic acid in the formation of “supersized” lipid droplets
Fei W, Shui G, Zhang Y, Krahmer N, Ferguson C, Kapterian TS, Lin RC, Dawes IW, Brown AJ, Li P, Huang X, Parton RG, Wenk MR, Walther TC, Yang H
PLoS Genet 7, e1002201 2011
doi: 10.1371/journal.pgen.1002201 PMID: 21829381 PMCID: PMC3145623

Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis
Harris C, Herker E, Farese RV, Jr., Ott M
J Biol Chem 286, 42615 2011
doi: 10.1074/jbc.M111.285148 PMID: 21984835 PMCID: PMC3234948

Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase
Krahmer N, Guo Y, Wilfling F, Hilger M, Lingrell S, Heger K, Newman HW, Schmidt-Supprian M, Vance DE, Mann M, Farese RV, Jr. and Walther TC
Cell Metab 14:504-515 2011
doi: 10.1016/j.cmet.2011.07.013 PMID: 21982710 PMCID: PMC3735358

2010

Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1
Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV Jr, Ott M
Nat Med 16(11):1295-8 2010
doi: 10.1038/nm.2238 PMID: 20935628 PMCID: PMC3431199

2008

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
Porstmann T, Santos CR, Griffiths B, Cully M, Wu M, Leevers S, Griffiths JR, Chung YL, Schulze A
Cell metabolism 8, 224 2008
doi: 10.1016/j.cmet.2008.07.007 PMID: 18762023 PMCID: PMC2593919

Ceramide triggers budding of exosome vesicles into multivesicular endosomes
Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brügger B, Simons M
Science 319:1244-1247 2008
doi: 10.1126/science.1153124 PMID: 18309083

2006

Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4
Milger K, Herrmann T, Becker C, Gotthardt D, Zickwolf J, Ehehalt R, Watkins PA, Stremmel W, Fullekrug J
J Cell Sci 119, 4678 2006
doi: 10.1242/jcs.03280 PMID: 17062637

1997

Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry
Brügger B, Erben G, Sandhoff R, Wieland FT, Lehmann WD
Proc Natl Acad Sci U S A 94(6):2339-44 1997
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