Project P5

Proteomic and lipidomic profiling of retinyl ester lipid droplets in hepatic stellate cells

Our aim is to identify targets that can inhibit or reverse hepatic stellate cell (HSC) activation, which is the crucial step in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) progression. HSCs undergo a transition from retinylester storage depots to pro-fibrogenic fibroblasts. We will leverage cutting-edge technologies to comprehensively describe and understand HSC biology and the cell biology of retinylester storage in a particular subtype of lipid droplets (LDs) employing a 3-step coordinated approach:

Principle Investigator