Natalie Krahmer

Natalie Krahmer has developed proteomic workflows to systematically map organelle compositions and interactions with a focus on LD composition and LD/organelle contact sites. In addition, she investigates how protein localization and modification correlate and how organelle proteomes are regulated by metabolic signaling pathways using phospho-proteomics.

ORCID: 0000-0003-4063-7367

Natalie.krahmer[at]helmholtz-muenchen.de

Krahmer lab

Select Publications

A spatiotemporal proteomic map of human adipogenesis
Klingelhuber F, Frendo-Cumbo S, Omar-Hmeadi M, Massier L, Kakimoto P, Taylor AJ, Couchet M, Ribicic S, Wabitsch M, Messias AC, Iuso A, Muller TD, Ryden M, Mejhert N and Krahmer N
Nat Metab 6:861-879 2024
doi: 10.1038/s42255-024-01025-8 PMID: 38565923 PMCID: PMC11132986

Distinct molecular profiles of skull bone marrow in health and neurological disorders
Kolabas ZI, Kuemmerle LB, Perneczky R, Forstera B, Ulukaya S, Ali M, Kapoor S, Bartos LM, Buttner M, Caliskan OS, Rong Z, Mai H, Hoher L, Jeridi D, Molbay M, Khalin I, Deligiannis IK, Negwer M, Roberts K, Simats A, Carofiglio O, Todorov MI, Horvath I, Ozturk F, Hummel S, Biechele G, Zatcepin A, Unterrainer M, Gnorich J, Roodselaar J, Shrouder J, Khosravani P, Tast B, Richter L, Diaz-Marugan L, Kaltenecker D, Lux L, Chen Y, Zhao S, Rauchmann BS, Sterr M, Kunze I, Stanic K, Kan VWY, Besson-Girard S, Katzdobler S, Palleis C, Schadler J, Paetzold JC, Liebscher S, Hauser AE, Gokce O, Lickert H, Steinke H, Benakis C, Braun C, Martinez-Jimenez CP, Buerger K, Albert NL, Hoglinger G, Levin J, Haass C, Kopczak A, Dichgans M, Havla J, Kumpfel T, Kerschensteiner M, Schifferer M, Simons M, Liesz A, Krahmer N, Bayraktar OA, Franzmeier N, Plesnila N, Erener S, Puelles VG, Delbridge C, Bhatia HS, Hellal F, Elsner M, Bechmann I, Ondruschka B, Brendel M, Theis FJ and Erturk A
Cell 186:3706-3725 e3729 2023
doi: 10.1016/j.cell.2023.07.009 PMID: 37562402 PMCID: PMC10443631

EPAC1 enhances brown fat growth and beige adipogenesis
Reverte-Salisa L, Siddig S, Hildebrand S, Yao X, Zurkovic J, Jaeckstein MY, Heeren J, Lezoualc’h F, Krahmer N and Pfeifer A
Nat Cell Biol 26:113-123 2024
doi: 10.1038/s41556-023-01311-9 PMID: 38195707 PMCID: PMC10791580

Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo
Kulaj K, Harger A, Bauer M, Caliskan OS, Gupta TK, Chiang DM, Milbank E, Reber J, Karlas A, Kotzbeck P, Sailer DN, Volta F, Lutter D, Prakash S, Merl-Pham J, Ntziachristos V, Hauner H, Pfaffl MW, Tschop MH, Muller TD, Hauck SM, Engel BD, Gerdes JM, Pfluger PT, Krahmer N and Stemmer K
Nat Commun 14:709 2023
doi: 10.1038/s41467-023-36148-1 PMID: 36759608 PMCID: PMC9911726

Spatial proteomics in three-dimensional intact specimens
Bhatia HS, Brunner AD, Ozturk F, Kapoor S, Rong Z, Mai H, Thielert M, Ali M, Al-Maskari R, Paetzold JC, Kofler F, Todorov MI, Molbay M, Kolabas ZI, Negwer M, Hoeher L, Steinke H, Dima A, Gupta B, Kaltenecker D, Caliskan OS, Brandt D, Krahmer N, Muller S, Lichtenthaler SF, Hellal F, Bechmann I, Menze B, Theis F, Mann M and Erturk A
Cell 185:5040-5058 e5019 2022
doi: 10.1016/j.cell.2022.11.021 PMID: 36563667

Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine
Niemann B, Haufs-Brusberg S, Puetz L, Feickert M, Jaeckstein MY, Hoffmann A, Zurkovic J, Heine M, Trautmann EM, Muller CE, Tonjes A, Schlein C, Jafari A, Eltzschig HK, Gnad T, Bluher M, Krahmer N, Kovacs P, Heeren J and Pfeifer A
Nature 609:361-368 2022
doi: 10.1038/s41586-022-05041-0 PMID: 35790189 PMCID: PMC9452294

The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology
Mejhert N, Gabriel KR, Frendo-Cumbo S, Krahmer N, Song J, Kuruvilla L, Chitraju C, Boland S, Jang DK, von Grotthuss M, Costanzo MC, Ryden M, Olzmann JA, Flannick J, Burtt NP, Farese RV, Jr. and Walther TC
Dev Cell 57:387-397 e384 2022
doi: 10.1016/j.devcel.2022.01.003 PMID: 35134345 PMCID: PMC9129885

Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis
Krahmer N, Najafi B, Schueder F, Quagliarini F, Steger M, Seitz S, Kasper R, Salinas F, Cox J, Uhlenhaut NH, Walther TC, Jungmann R, Zeigerer A, Borner GHH and Mann M
Dev Cell 47:205-221 e207 2018
doi: 10.1016/j.devcel.2018.09.017 PMID: 30352176

Protein correlation profiles identify lipid droplet proteins with high confidence
Krahmer N, Hilger M, Kory N, Wilfling F, Stoehr G, Mann M, Farese RV, Jr. and Walther TC
Mol Cell Proteomics 12:1115-1126 2013
doi: 10.1074/mcp.M112.020230 PMID: 23319140 PMCID: PMC3650325

Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase
Krahmer N, Guo Y, Wilfling F, Hilger M, Lingrell S, Heger K, Newman HW, Schmidt-Supprian M, Vance DE, Mann M, Farese RV, Jr. and Walther TC
Cell Metab 14:504-515 2011
doi: 10.1016/j.cmet.2011.07.013 PMID: 21982710 PMCID: PMC3735358

Career

Education