Marteinn Snaebjörnsson

Marteinn Snaebjörnsson has investigated metabolism during development with a focus on glycolytic flux and has recently shifted his research focus on lipid metabolism during cancerogenesis.

ORCID: 0009-0008-4457-5726

m.snaebjoernsson[at]dkfz-heidelberg.de

Snaebjörnsson lab

Select Publications

Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation
Snaebjornsson MT, Poeller P, Komkova D, Röhrig F, Schlicker L, Winkelkotte AM, Chaves-Filho AB, Al-Shami KM, Caballero CD, Koltsaki I, Vogel FCE, Frias-Soler RC, Rudalska R, Schwarz JD, Wolf E, Dauch D, Steuer R, Schulze A
Nat Metab Feb;7(2):348-366 2025
doi: 10.1038/s42255-024-01201-w PMID: 39833612 PMCID: PMC11860237

Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer
Buglakova E, Ekelöf M, Schwaiger-Haber M, Schlicker L, Molenaar MR, Shahraz M, Stuart L, Eisenbarth A, Hilsenstein V, Patti GJ, Schulze A^#, Snaebjornsson MT^#, Alexandrov T^# - ^#shared corresponding authorship
Nat Metab Sep;6(9):1695-1711 2024
doi: 10.1038/s42255-024-01118-4 PMID: 39251875 PMCID: PMC11422168

mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism
Levy T, Voeltzke K, Hruby L, Alasad K, Bas Z, Snaebjörnsson M, Marciano R, Scharov K, Planque M, Vriens K, Christen S, Funk CM, Hassiepen C, Kahler A, Heider B, Picard D, Lim JKM, Stefanski A, Bendrin K, Vargas-Toscano A, Kahlert UD, Stühler K, Remke M, Elkabets M, Grünewald TGP, Reichert AS, Fendt SM, Schulze A, Reifenberger G, Rotblat B, Leprivier G
Nat Commun 15(1):4083 2024 doi: 10.1038/s41467-024-48386-y PMID: 38744825 PMCID: PMC11094136

Targeting MYC induces lipid droplet accumulation by upregulation of HILPDA in clear cell renal cell carcinoma
Sainero-Alcolado L, Garde-Lapido E, Snaebjörnsson MT, Schoch S, Stevens I, Ruiz-Pérez MV, Dyrager C, Pelechano V, Axelson H, Schulze A, Arsenian-Henriksson M.
Proc Natl Acad Sci U S A 121(7):e2310479121 2024
doi: 10.1073/pnas.2310479121 PMID: 38335255 PMCID: PMC10873620

Glycolytic flux-signaling controls mouse embryo mesoderm development
Miyazawa H, Snaebjornsson MT, Prior N, Kafkia E, Hammarén HM, Tsuchida-Straeten N, Patil KR, Beck M, Aulehla A - *contributed equally
Elife 11:e83299 2022
doi: 10.7554/eLife.83299 PMID: 36469462 PMCID: PMC9771359

The glycolytic enzyme ALDOA and the exon junction complex protein RBM8A are regulators of ribosomal biogenesis
Schwarz JD, Lukassen S, Bhandare P, Eing L, Snaebjörnsson MT, García YC, Kisker JP, Schulze A, Wolf E
Front Cell Dev Biol 10:954358 2022
doi: 10.3389/fcell.2022.954358 PMID: 36187487 PMCID: PMC9515781

MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer
Kalogirou C, Linxweiler J, Schmucker P, Snaebjornsson MT, Schmitz W, Wach S, Krebs M, Hartmann E, Puhr M, Muller A, Spahn M, Seitz AK, Frank T, Marouf H, Buchel G, Eckstein M, Kubler H, Eilers M, Saar M, Junker K, Rohrig F, Kneitz B, Rosenfeldt MT, Schulze A
Nat Commun 12:5066 2021
doi: 10.1038/s41467-021-25325-9 PMID: 34417456 PMCID: PMC8379214

LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer
Rudalska R, Harbig J, Snaebjornsson MT, Klotz S, Zwirner S, Taranets L, Heinzmann F, Kronenberger T, Forster M, Cui W, D’Artista L, Einig E, Hinterleitner M, Schmitz W, Dylawerska A, Kang TW, Poso A, Rosenfeldt MT, Malek NP, Bitzer M, Laufer S, Pichler BJ, Popov N, Schulze A, Zender L, Dauch D
Nat Cancer 2(2):201-217 2021
doi: 10.1038/s43018-020-00168-3 PMID: 35122079

Inhibition of fatty acid synthesis induces differentiation and reduces tumor burden in childhood neuroblastoma
Ruiz-Pérez MV, Sainero-Alcolado L, Oliynyk G, Matuschek I, Balboni N, Ubhayasekera SJKA, Snaebjornsson MT, Makowski K, Aaltonen K, Bexell D, Serra D, Nilsson R, Bergquist J, Schulze A, Arsenian-Henriksson M
iScience 24(2):102128 2021 doi: 10.1016/j.isci.2021.102128 PMID: 33659885 PMCID: PMC7895756

Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development
Bulusu V, Prior N, Snaebjornsson MT, Kuehne A, Sonnen KF, Kress J, Stein F, Schultz C, Sauer U, Aulehla A - contributed equally
Dev Cell 40(4):331-341.e4 2017
doi: 10.1016/j.devcel.2017.01.015 PMID: 28245920 PMCID: PMC5337618

Differential water permeability and regulation of three aquaporin 4 isoforms
Fenton RA, Moeller HB, Zelenina M, Snaebjornsson MT, Holen T, MacAulay N
Cell Mol Life Sci 67(5):829-40 2010
doi: 10.1007/s00018-009-0218-9 PMID: 20013023 PMCID: PMC11115813

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