Britta Brügger

Britta Brügger is a specialist in membrane biochemistry and pioneered the use of MS for lipid analysis. Her laboratory has a longstanding expertise in biochemistry, chemical biology, and molecular cell biology. In order to study the role of lipids in membrane dynamics, the Brügger lab has developed novel key technologies to study protein-lipid interactions and to quantitatively assess membrane lipids that represent the state-of-the-art in lipidomics.

ORCID: 0000-0002-3477-8270

britta.bruegger[at]bzh.uni-heidelberg.de

Brügger lab

Select Publications

Quantification of Dolichyl Phosphates Using Phosphate Methylation and Reverse-Phase Liquid Chromatography-High Resolution Mass Spectrometry
Kale D^#, Kikul F, Phapale P, Beedgen L, Thiel C, Brügger B^#
Anal Chem 95(6):3210-3217 2023
doi: 10.1021/acs. analchem.2c03623 PMID: 36716239 PMCID: PMC9933046

Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins
Nůsková H, Serebryakova MV, Ferrer-Caelles A, Sachsenheimer T, Lüchtenborg C, Miller AK, Brügger B, Kordyukova LV, Teleman AA
Nat Commun 12:4590 2021
doi: 10.1038/s41467-021-24844-9 PMID: 34321466 PMCID: PMC8319428

Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
Malek M, Wawrzyniak AM, Koch P, Lüchtenborg C, Hessenberger M, Sachsenheimer T, Jang W, Brügger B, Haucke V
Nat Commun 12(1):2673 2021
doi: 10.1038/s41467-021-22882-x PMID: 33976123 PMCID: PMC8113574

Heme binding of transmembrane signaling proteins undergoing regulated intramembrane proteolysis
Kupke T^#, Klare JP, Brügger B^#
Commun Biol 3:73 2020
doi: 10.1038/s42003-020-0800-0 PMID: 32060393 PMCID: PMC7021776

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity
Hammerschmidt P, Ostkotte D, Nolte H, Gerl MJ, Jais A, Brunner HL, Sprenger HG, Awazawa M, Nicholls HT, Turpin-Nolan SM, Langer T, Krüger M, Brügger B, and Brüning JC
Cell 177:1536-1552 e1523 2019
doi: 10.1016/j.cell.2019.05.008 PMID: 31150623

Analysis of transmembrane domains and lipid modified peptides with matrix-assisted laser desorption ionization-time-of-flight mass spectrometry
Gerl MJ^#, Sachsenheimer T, Grzybek M, Coskun U, Wieland FT, Brügger B^#
Anal Chem 86(8):3722-6 2014
doi: 10.1021/ac500446z PMID: 24628620

Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain
Contreras FX, Ernst AM, Haberkant P, Björkholm P, Lindahl E, Gonen B, Tischer C, Elofsson A, von Heijne G, Thiele C, Pepperkok R, Wieland F^#, Brügger B^#
Nature 481:525-529 2012
doi: 10.1038/nature10742 PMID: 22230960

Ceramide triggers budding of exosome vesicles into multivesicular endosomes
Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brügger B, Simons M
Science 319:1244-1247 2008
doi: 10.1126/science.1153124 PMID: 18309083

Molecular anatomy of a trafficking organelle
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, Rammner B, Gräter F, Hub JS, De Groot BL, Mieskes G, Moriyama Y, Klingauf J, Grubmüller H, Heuser J, Wieland F, Jahn R
Cell 127(4):831-46 2006
doi: 10.1016/j.cell.2006.10.030 PMID: 17110340

Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry
Brügger B, Erben G, Sandhoff R, Wieland FT, Lehmann WD
Proc Natl Acad Sci U S A 94(6):2339-44 1997
doi: 10.1073/pnas.94.6.2339 PMID: 9122196 PMCID: PMC20089

Career

Education